Sugar increases hypertension

All 12 studies in a May, 2014, meta-analysis found that sugar elevates blood pressure. The study called “Impact of Sugar-Sweetened Beverages on Blood Pressure” was published in the American Journal of Cardiology.

Sugar increases hypertension

Soft drinks easily earn the name “liquid candy,” because they contain an average of 10 teaspoons of sugar per can. Soft drinks are the largest source of added sugar in our diet. These drinks are often cheaper than bottled water and become the liquid of choice for most of the population.

In the U.S., high-fructose corn syrup (HFCS) is the major source of added sugar in soft drinks. HFCS has only been around since 1975. It’s marketed as a safe and natural fruit sugar — fructose. However, if you watch the Sugar: The Bitter Truth video lecture by Pediatric Endocrinologist Dr. Robert Lustig, you quickly learn that fructose is even more dangerous than table sugar — sucrose.

Drinking liquid candy is associated with obesity, diabetes, heart disease and kidney stones, and now this analysis confirms that it increases the incidence of high blood pressure. I could add the follow effects of sugar: yeast overgrowth, arrhythmia, bowel disease, rashes, lowered immune system and allergies. In my Death by Modern Medicine book, I quote Nancy Appleton’s “146 Reasons Why Sugar is Ruining Your Health,” with references.

Lustig found that, in a large meta-analysis of soft drinks and obesity, 88 studies all show significant association of obesity with increased soft drink consumption. Sugar industry studies showed lesser effects, and they claim that soft drinks do not cause obesity. However, studies limiting consumption of soft drinks in kids show that obesity decreases. Weight gain is another factor associated with high blood pressure

Researchers say they don’t really know how sugar causes high blood pressure, but in the sugar impact study, the authors discuss several theories. Apparently, liquid candy can lower nitric oxide in the body, which causes blood vessels to constrict and blood pressure to rise. Since soft drinks can contain extra salt, they theorize that that may be the cause. They may not know what causes the hypertension, but they do conclude, “On the basis of these studies, there is a suggestion that intake of greater than one serving of sugar-sweetened beverage per day is associated with higher risk of hypertension.”

I have a different theory. Lustig talks about the extra energy used by the liver to metabolize fructose compared with sucrose, but he doesn’t mention magnesium. A fascinating and little-known fact about sugar metabolism is that 28 molecules of magnesium are required to break down one molecule of sucrose, and 56 molecules of magnesium are used up to metabolize one molecule of fructose.

When magnesium is diminished to that extent, the resulting magnesium deficiency can contribute to raising the blood pressure, because magnesium is required to relax the muscles of the body including the smooth muscles of the blood vessels. If there is tension in the smooth muscles of the blood vessels, then the blood pressure rises.

Nitric oxide is mentioned in the blood pressure study and also by Lustig. But nitric oxide is controlled by magnesium. This is what I write in The Magnesium Miracle: “Smooth muscle cells provide integrity and control the dilation of the arterial cavity, triggered by the calcium/magnesium ratio in the body. Calcium causes contraction and magnesium causes relaxation, which together control the blood pressure and flow in the artery. A final messenger for the dilation response is nitric oxide, which is dependent on magnesium.”

What do I recommend? Avoid high-fructose corn syrup, of course. Take supplemental magnesium and also make and take your own Liposomal Vitamin C. Magnesium and vitamin C are the antidotes to a sugar binge! You can go to my Blog to find the recipe for making your own Liposomal Vitamin C and also see my recommendation for the best form of magnesium to take.

Source: natural news

New drug can lower salt intake without any dietary changes

Sodium: An important dietary element that the body needs to function. But too much of the chemical can potentially be deadly.

Given current diet trends, a significant majority of Americans consume too much sodium from their food, contributing to an overall increase in cardiovascular disease and poor kidney function. But soon, a new drug may be able to solve this growing problem – by lowering an individual’s salt absorption without affecting his or her diet.

The medication could potentially help the millions of Americans who suffer from chronic kidney disease (CKD) and hypertension, but who have a hard time adhering to a low-sodium diet.

Developed by researchers at drug manufacturer Ardelyx, the drug, tenapanor, works by blocking a membrane transporter called NH3, which is responsible for most of the reuptake of sodium in the body. By inhibiting this protein, the majority of sodium is prevented from seeping into the bloodstream and instead remains in the gut.

“It’s a small molecule that’s been designed to remain within the gut, acting on this transporter that is expressed in the mucosa in the GI (gastrointestinal) tract,” lead researcher Dominique Charmot, co-founder and chief scientific officer at Ardelyx, told “And in doing so, what it does is divert sodium from going into the blood to going into the stool. So that increases sodium in the stool and avoids building up too much sodium in the body.”

According to Charmot, current medications to control sodium include diuretics and antihypertensive drugs, which either increase water excretion or control high blood pressure. However, these drugs require patients to adhere to a diet very low in sodium – a feat that can be difficult given the high prevalence of the chemical in typical American diets. But since tenapanor remains in the gut, the drug can remove the sodium while patients continue to eat their normal diet.

To test the effectiveness of tenapanor, Charmot and lead study author Andrew Spencer, senior director for research and development at Ardelyx, administered the drug to rats that had fractions of their kidneys removed, in order to emulate patients with CKD. They also continued feeding the rats a high-sodium diet to see how it interfered with the drug’s success.

“What we’ve shown in this rat model is it protects against hypertension and hypertrophy (an increase in volume) of the heart; and it protects against further damage of the kidney, which is shown by the presence of protein in the urine,” Charmot said.

Additionally, tenapanor was given to patients with CKD in a phase 1 proof of concept study. After taking the medication, patients showed an increase of sodium in their stools and no presence of the drug was detected in their bloodstreams – proving the drug adhered to its design and function.

Charmot and his team hope that their drug will benefit many in the United States, especially given Americans’ widespread consumption of sodium on a daily basis. The U.S. Dietary Guidelines recommend people should limit their sodium to less than 2,300 milligrams a day, but the Centers for Disease Control and Prevention (CDC) estimates that the average American eats more than 3,300 milligrams daily. In fact, the CDC found that more than 90 percent of Americans over the age of 2 eat too much sodium.

Experts believe these dietary trends have contributed to the rising incidence of chronic diseases in the United States. The CDC states that 26 million Americans suffer from CKD and approximately 67 million people have high blood pressure – equating to 1 in 3 U.S. citizens.

And the sodium-related health problems don’t simply stop there, according to Charmot.

“A new body of science is emerging which tells us that sodium, independent of blood pressure, is bad. There’s a lot of animal data showing salt can induce scar tissue in the kidneys and in the vasculature – something that’s seen, for example, by the thickness of the arteries.”

Because of sodium’s potential to contribute to so many diseases, the researchers believe tenapanor can help many individuals stay healthy while enjoying a normal dietary routine.

“It’s fair to say that asking patients to maintain a low-sodium diet is very hard to do,” Charmot said. “…Most of the food additives contain sodium; people who eat in restaurants cannot control sodium; plus, food is bland without sodium. Also there’s a risk if you go too low in sodium, you also diminish nutrient composition which is needed for you to thrive. So we believe this drug can help patients comply with a more normal diet.”

The research on tenapanor was published online in the journal Science.

Source: health medicine

Eating vegetarian diets may help lower BP

A new study has revealed that eating a vegetarian diet is associated with lower blood pressure (BP), and the diets can also be used to reduce blood pressure.

Factors such as diet, body weight, physical activity and alcohol intake play a role in the risk of developing hypertension. Dietary modifications have been shown to be effective for preventing and managing hypertension.

The authors analyzed seven clinical trials and 32 studies published from 1900 to 2013 in which participants ate a vegetarian diet. Net differences in BP associated with eating a vegetarian diet were measured.

In the trials, eating a vegetarian diet was associated with a reduction in the average systolic (peak artery pressure) and diastolic (minimum artery pressure) BP compared with eating an omnivorous (plant and animal) diet.

In the 32 studies, eating a vegetarian diet was associated with lower average systolic and diastolic BP, compared with omnivorous diets.

The study was published in the journal JAMA.

Source: DNA India

Sleep disturbances linked to poor quality of life in obese

A new research has showed that poor sleep quality is strongly associated with mood disturbance and lower quality of life among people with extreme obesity.

Results show that 74.8 percent of participants were poor sleepers, and their mean self-reported sleep duration was only six hours and 20 minutes.

Fifty-two percent of study subjects were anxious, and 43 percent were depressed. After controlling for age, sex, hypertension, diabetes, and obstructive sleep apnea, sleep quality and daytime sleepiness were significantly associated with mood disturbance and quality of life impairment.

“There was a clear association between the sleep problems such as short sleep duration and the psychological disorders and with quality of life,” Dr. G. Neil Thomas, from the University of Birmingham in the United Kingdom, said. “These associations remained significant even after adjusting for a range of potential confounders.

According to the authors, the potential role of sleep in the health and well-being of individuals with severe obesity is underappreciated. The results suggested that the early detection of disturbed sleep could prevent the potential development and perpetuation of psychological problems among people with extreme obesity.

The study was published in the journal Sleep.
Source: dna India

Global gaps in high blood pressure knowledge, treatment

41 percent had consistently high blood pressure, but fewer than half of those people knew it.

It`s the leading contributor to deaths worldwide yet most people with high blood pressure don`t know they have the condition and even for those who do, treatment is mostly ineffective, according to a large new study.

Researchers examined more than 140,000 adults in 17 countries and found that about 41 percent had consistently high blood pressure, also known as hypertension, but fewer than half of those people knew it.

“We found that surprisingly many people didn`t realize their blood pressure was high,” lead author Clara Chow, from The George Institute for Global Health in Sydney, Australia, said.

Less than a third of those aware of their condition and getting treatment had their blood pressure under control, with poor and rural populations faring the worst.

“Whereas in high-income countries a larger proportion of people knew they had hypertension and were on treatment than people in low-income countries, the control problem was significant wherever you were,” Chow said.

Normal blood pressure is defined as a systolic reading (the top number) of 120 millimeters of mercury (mm Hg) or less and a diastolic reading (the bottom number) of 80 mm Hg or less.

The National Institutes of Health estimates that one in three U.S. adults has high blood pressure, which can lead to heart disease, heart failure, stroke and kidney failure.

High blood pressure is the leading cause of heart disease and strokes, which are the top two causes of death worldwide, according to the World Health Organization.

Globally, hypertension is tied to “at least” 7.6 million deaths each year, Chow`s team writes in The Journal of the American Medical Association.

Despite the condition`s worldwide impact, Chow told Reuters Health, there hasn`t been much research on how it should be targeted to bring down the incidence of cardiovascular disease.

For the new study, she and her colleagues from several research centers around the world recruited 142,042 adults in 17 countries of varying income levels to be examined between January 2003 and December 2009.

They defined the condition either by a participant`s self report of having been diagnosed with hypertension, or by two blood pressure readings of at least 140/90 mm Hg.

Overall, 57,840 of the participants had high blood pressure, but only 26,877 were aware of their condition.

The vast majority of those who were aware were taking some sort of medication – often two medications – to treat high blood pressure, but only about one third were successfully controlling the disease.

“People who knew they had hypertension, about 88 percent were initiated on some sort of treatment. However the control of their blood pressure was poor,” Chow said.

When researchers looked at the results by country, they found that in high-income and upper-middle-income countries, around 50 percent of people with high blood pressure were aware of their condition and around 47 percent were getting treatment.

In comparison, in lower-income and lower-middle-income countries around 42 percent of people with hypertension were aware of it and about 34 percent were treated.

In poorer countries, awareness, treatment and control of high blood pressure were better in urban areas compared to rural ones, and among better educated people, the researchers note.

Dr. Jorge Plutzky, director of the Vascular Disease Prevention Program at Brigham and Women`s Hospital in Boston, said the new study confirms previous findings on blood pressure around the world and adds to what is known by showing the differences between urban and rural areas.

“I think it`s another stimulant to get a variety of groups to look at and think about this issue,” Plutzky, who was not involved in the new study, said.

For example, he said, international groups have been effective in combating a variety of infectious diseases throughout the world.

“We need those same kinds of groups to also start thinking about chronic diseases,” he said, adding that techniques developed overseas can also be brought back to rural areas in the U.S.

Chow said the focus should be on finding ways to detect high blood pressure in people in different places around the world, and removing barriers to treatment, including costs and transportation to and from doctors` offices.

Source: Zee News