Iron supplementation does not increase susceptibility to malaria

Kids in a malaria-endemic community in Ghana, who received a micronutrient powder with iron did not have an increased incidence of malaria, a study has claimed.

Previous research has suggested that iron supplementation for children with iron deficiency in malaria-endemic areas may increase the risk of malaria.

Stanley Zlotkin, M.D., Ph.D., of the Hospital for Sick Children, Toronto, and colleagues conducted a study to determine the effect of providing micronutrient powder (MNP) with or without iron on the incidence of malaria among children living in a high malaria-burden area.

The randomized trial, which included children 6 to 35 months of age (n = 1,958 living in 1,552 clusters), was conducted over 6 months in 2010 in a rural community setting in central Ghana, West Africa.

A cluster was defined as a compound including 1 or more households. Children were excluded if iron supplement use occurred within the past 6 months; they had severe anemia, or severe wasting.

Children were randomized by cluster to receive a MNP with or without iron for 5 months followed by 1-month of further monitoring. Insecticide-treated bed nets were provided at enrollment, as well as malaria treatment when indicated.

Throughout the intervention period, adherence to the use of MNP and insecticide-treated bed nets were similar between the iron group and the no iron group.

The study has been published in JAMA.

 


A look at the 4 weirdest cosmetic procedures

cosmetic procedures which are downright weird and at the same time very risky.

Not to forget the huge amounts of money that goes down the drain even if you end up with a botched up job. Here’s a list of cosmetic procedures which are downright weird and at the same time very risky.

Joker smile surgery

Want a permanently fixed smile on your face, even when you are sad? This is what the joker smile surgery will do for you. The procedure will curl up the corners of your lips by altering your facial muscles and their setting especially the jaw muscles which are responsible for giving you a droopy smile as they pull the lips downwards. The procedure is permanent in nature and if goes wrong, can result in a botched up face. Dr Rashmi Shetty, a well-known cosmetologist and a leading expert in non-surgical aesthetic medicine warns that this surgery can severely affect facial muscles and requires a lot of precision since the muscles are very delicate. She suggests opting for a couple of units of BOTOX on the DAO muscle (a facial muscle near the mouth) which straightens out the droopy smile and takes hardly two minutes. In case you don’t like it, it wears off in three months and you can go back to your natural look.

Palm plastic surgery

The Japanese seem to love this new trend with thousands flocking to plastic surgeons to get their palm lines fixed. If you are wondering what could be the possible reason for correcting the lines on your palms, lo and behold – it’s done to bring luck or change your fate! The belief that these lines tell you what your future holds is prevalent in India as well. And if you aren’t too happy about the outcome, go and get it changed in a mere 15 minutes. Lines of luck, marriage, etc are added or modified according to a person’s liking using an electric scalpel for making shaky incisions on the palms. About five to 10 lines are altered or added in 15 minutes. Dr Shetty advises against this procedure as the hands and palms have various nerves which are needed for the proper functioning of one’s body. Any kind of mishap can damage not only your palms but also these nerves and your entire body.

Toe tuck

Not too happy with your feet? Think they’re too broad or the toes too short or long? Toe tuck surgery fixes all such problems. If you’ve ruined your feet by wearing stilettos for years and want to correct the shape and wear them again, toe tucks are for you. The results however aren’t permanent and the procedure is quite painful too. In a bid to wear strappy shoes and pumps, you might end up with a boneless toe. Not only this, it can cause nerve damage if not done correctly.

Cosmetic surgery for pets

As if procedures on humans weren’t enough, pets too have been dragged into this tomfoolery to look perfect! Cosmetic surgeries like tummy tuck, ear implants and even pet braces are doing the rounds in pet circles where owners who wish to enhance the appearance of their pets can go ahead with such treatments. While some do it to benefit the animal and improve their health, some just do it as they aren’t too happy with their canine’s appearance.

Source: Zee News:


Differences in lung function have major health impact

A global study has suggested that large differences in lung function between healthy people from different socioeconomic and geographical regions of the world could impact their health.

The large differences in lung function could not be accounted for by variations across regions in height, weight, age, gender, education levels and rural or urban location.

Dr. MyLinh Duong, lead author of the paper and an assistant professor of medicine of the Michael G. DeGroote School of Medicine at McMaster University, said that the findings have important public health implications, as there is a well known link between low lung function and increased mortality.

Researchers at McMaster University said that these differences may be genetically determined, but more likely most relate to the socio-economic, nutritional and environmental exposures of people in the different regions. These are all conditions that could be modified or improved.

Respirologist Dr. Paul O“Byrne, who is the co-author of the paper, said that these findings are of great importance, as we need separate standards for what is considered normal in different parts of the world and may lead us to rethink how to define those with abnormal lung function.

The study included 154,000 adult non-smokers between 35 and 70 years old from 17 countries from four continents.

Some of the factors such as nutrition and pollution levels will be explored in future analysis of the study.

The study is published in the journal, The Lancet Respiratory Medicine.

 


Fish oil could help alcohol abusers keep dementia at bay

A new research has suggested that omega-3 fish oil may help protect against alcohol-related dementia.

The study, Loyola University Chicago Stritch School of Medicine, found that in the brain cells of rats exposed to high levels of alcohol, a fish oil compound protected against inflammation and cell death.

In the study, Michael A. Collins, PhD, and colleagues exposed cultures of adult rat brain cells to amounts of alcohol equivalent to more than four times the legal limit for driving.

These cell cultures were compared with cultures of brain cells exposed to the same high levels of alcohol, plus a compound found in fish oil called omega-3 docosahexaenoic acid (DHA).

Researchers found there was about 90 percent less neuro inflammation and neuronal death in the brain cells exposed to DHA and alcohol than in the cells exposed to alcohol alone.

 


New method could help in early detection of colon cancer

Bettina Scholtka, said that tumour cells are released into stool from the surface of precancers and early-stage colon cancers

Scientists have found a new method to detect genetic variations that initiate colon cancer could be readily used for non-invasive colon cancer screening.

Bettina Scholtka, Ph.D., assistant professor in the Department of Nutritional Toxicology at the University of Potsdam in Nuthetal, Germany, said that tumour cells are released into stool from the surface of precancers and early-stage colon cancers, but detecting a cancer-initiating genetic mutation among a large quantity of normal DNA from a patient’s stool is like looking for a needle in a haystack.

Scholtka said that by combining for the first time locked nucleic acid-based, wild-type blocking polymerase chain reaction and high-resolution melting, we were able to achieve the desired sensitivity.

Scholtka and colleagues used 80 human colon tissue samples representing cancers and precancers to detect genetic variations using a combination of two techniques: The first technique — locked nucleic acid (LNA)-based, wild-type blocking (WTB) polymerase chain reaction — suppressed normal DNA present in large quantities in the sample; and the second technique — high-resolution melting (HRM) — enhanced the detection of genetic variations.

The researchers were able to detect APC variations in 41 of the 80 samples. They were also able to detect previously unknown variations in APC. In contrast, the routinely used technique called direct sequencing could detect variations only in 28 samples.

They then analyzed 22 stool samples from patients whose colon tissues had APC variations, and nine stool samples from patients whose colon tissues did not have APC variations, as controls. They were able to detect APC variations in 21 out of 22 samples.

The study has been published in Cancer Prevention Research.


15% of common strokes occur in adolescents and young adults

A team of researcher including an Indian origin has suggested that 15 percent of the most common type of strokes occur in adolescents and young adults, and more young people are showing risk factors for such strokes.

Co-author neurologist Jose Biller of Loyola University Medical Center said that the impact of strokes in this age group is devastating to the adolescent or young adult, their families and society.

About 85 percent of all strokes are ischemic, meaning they are caused by blockages that block blood flow to the brain. And more young people have risk factors for ischemic strokes.

Those risks include high blood pressure, diabetes, obesity, abnormal cholesterol levels, congenital heart disease and smoking.

Strokes in young people have a disproportionally large economic impact, because they can disable patients before their most productive years. And while coping with the shock of having a stroke, “younger survivors may be dealing with relationships, careers and raising children – issues that require additional awareness and resources,” the consensus report said.

Biller, one of the nation’s leading experts on stroke in young people, is second author of the consensus report. Biller is chair of the Department of Neurology of Loyola University Chicago Stritch School of Medicine. First author of the report is Aneesh Singhal, MD of Massachusetts General Hospital.

The study has been published in the journal Neurology.

 


Genetic cause of childhood leukemia revealed

Scientists have uncovered a genetic link specific to the risk of childhood leukaemia.

Study author Kenneth Offit, MD, MPH, Chief of the Clinical Genetics Service at Memorial Sloan-Kettering Cancer Center, said that at the very least the discovery gives us a new window into inherited causes of childhood leukemia.

Offit said that more immediately, testing for this mutation may allow affected families to prevent leukemia in future generations.

The mutation was first observed in a family treated at Memorial Sloan-Kettering of which several family members of different generations had been diagnosed with childhood acute lymphoblastic leukemia (ALL).

A second, non-related, leukemia-prone family cared for at a different hospital was later found to have the same mutation. A series of experiments were conducted confirming that the observed mutation compromised the normal function of the gene, which may increase the risk of developing ALL.

The inherited genetic mutation is located in a gene called PAX5, which is known to play a role in the development of some B cell cancers, including ALL.

The findings have been published in the journal Nature Genetics.

 


Yoga may benefit prisoners psychologically

Yoga can improve the mood and mental well being of prisoners and may also affect their impulsive behaviour, a study has revealed.

The researchers at the Oxford University have found that prisoners after a ten-week yoga course reported improved mood, reduced stress and were better at a task related to behaviour control than those who continued in their normal prison routine.
“We found that the group that did the yoga course showed an improvement in positive mood, a decrease in stress and greater accuracy in a computer test of impulsivity and attention,” Dr Amy Bilderbeck and Dr Miguel Farias, who led the study at the Departments of Experimental Psychology and Psychiatry at Oxford University, said.

“The suggestion is that yoga is helpful for these prisoners,” they further explained.

The study has been presented in the Journal of Psychiatric Research.


F.D.A. Approves a Drug for Late-Stage Pancreatic Cancer

In a clinical trial, the Celgene drug Abraxane prolonged the lives of patients by a little less than two months on average.

The Food and Drug Administration on Friday approved Celgene’s drug Abraxane for use in treating advanced pancreatic cancer, supplementing the thin arsenal available to fight the disease.

In a clinical trial, Abraxane prolonged the lives of patients by a little less than two months on average. Pancreatic specialists have said the drug was a welcome, if modest, advance against a disease that is extremely tough to treat.

“Patients with pancreatic cancer are often diagnosed after the cancer has advanced and cannot be surgically removed,” Dr. Richard Pazdur, director of cancer drugs for the F.D.A., said in a statement on Friday. “In these situations, and in situations where the cancer has progressed following surgery, options like Abraxane can help prolong a patient’s life.”

There will be about 45,000 new cases of pancreatic cancer diagnosed in the United States this year and about 38,000 deaths, making it the fourth-leading cause of cancer death.

Patients with metastatic pancreatic cancer typically live only half a year. For years, researchers have tried to improve that by adding drugs to the standard treatment, gemcitabine, but without notable success.

Abraxane did provide a statistically significant improvement in survival. In its main clinical trial, patients who received Abraxane and gemcitabine lived a median of 8.5 months, compared to 6.7 months for those receiving only gemcitabine.

Abraxane will compete with Folfirinox, a combination of four generic drugs. Folfirinox appears to extend survival by a greater amount than Abraxane, but doctors say it is harder to tolerate and administer.

Abraxane is a novel form of paclitaxel, also known by the brand name Taxol. In Abraxane, the paclitaxel is bound in tiny particles to albumin, a human protein. That is said to enhance delivery of the drug to the tumor and reduce side effects.

Still, Abraxane can depress levels of white blood cells and platelets and raise the risk of bacterial blood stream infections and lung inflammation, the F.D.A. said.

Abraxane was approved to treat breast cancer in 2005 and lung cancer in 2012. Sales last year were $427 million. Celgene’s total revenue that year was $5.5 billion, mostly from the multiple myeloma drug Revlimid.

Geoffrey Meacham, a biotechnology analyst at J. P. Morgan, said in a note on Friday that he expected Abraxane to “rapidly becomes the standard of care” for pancreatic cancer. He said sales for that use could eventually exceed $750 million annually.

Celgene said the drug would cost $6,000 to $8,000 a month.

Source: Newyork times

 


Is there an anti-inflammatory diet?

foods-for-inflammation

When inflammation is out of control—as in rheumatoid arthritis—it can damage the body.

Inflammation is part of the body’s immune response; without it, we can’t heal. But when it’s out of control—as in rheumatoid arthritis—it can damage the body. Plus, it’s thought to play a role in obesity, heart disease, and cancer.

Foods high in sugar and saturated fat can spur inflammation. “They cause overactivity in the immune system, which can lead to joint pain, fatigue, and damage to the blood vessels,” says Scott Zashin, MD, clinical professor at the University of Texas Southwestern Medical Center in Dallas.

Other foods may curb inflammation. Add these items to your plate today.

14 foods that fight Inflammation

Beetroot

This vegetable’s brilliant red color is a tip-off to its equally brilliant antioxidant properties: Beets (and beetroot juice) have been shown to reduce inflammation, as well as protect against cancer and heart disease, thanks to their hearty helping of fiber, vitamin C and plant pigments called betalains.

Fatty Fish

Oily fish, like salmon, mackerel, tuna and sardines, are high in omega-3 fatty acids, which have been shown to help reduce inflammation. To get the benefits, however, you need to eat fish several times a week, and it should be cooked in healthy way

Whole Grains

Consuming most of your grains as whole grains, as opposed to refined, white bread, cereal, rice, and pasta can help keep harmful inflammation at bay. That’s because whole grains have more fiber, which has been shown to reduce levels of C-reactive protein, a marker of inflammation in the blood, and they usually have less added sugar.

Dark Leafy Greens

Studies have suggested that vitamin E may play a key role in protecting the body from pro-inflammatory molecules called cytokines—and one of the best sources of this vitamin is dark green veggies, such as spinach, kale, broccoli, and collard greens. Dark greens and cruciferous vegetables also tend to have higher concentrations of vitamins and minerals—like calcium, iron, and disease-fighting phytochemicals—than those with lighter-colored leaves.

Nuts:

Another source of inflammation-fighting healthy fats is nuts—particularly almonds, which are rich in fiber, calcium, and vitamin E, and walnuts, which have high amounts of alpha-linolenic acid, a type of omega-3 fat. All nuts, though, are packed with antioxidants, which can help your body fight off and repair the damage caused by inflammation. Nuts (along with fish, leafy greens, and whole grains) are a big part of the Mediterranean diet, which has been shown to reduce inflammation in as little as six weeks.

Soy:

Several studies have suggested that isoflavones, estrogen-like compounds found in soy products, may help lower CRP and inflammation levels in women—and a 2007 animal study published in the Journal of Inflammation found that isoflavones also helped reduce the negative effects of inflammation on bone and heart health in mice.

Low fat Diary:

Milk products are sometimes considered a trigger food for inflammatory diseases like rheumatoid arthritis, because some people have allergies or intolerances to casein, the protein found in dairy. But for people who can tolerate it, low-fat and nonfat milk are an important source of nutrients. Yogurt can also contain probiotics, which can reduce gut inflammation.

Peppers:

Colorful vegetables are part of a healthier diet in general,” says Dr. Costenbader. “As opposed to white potatoes or corn, colorful peppers, tomatoes, squash, and leafy vegetables have high quantities of antioxidant vitamins and lower levels of starch.” Bell peppers are available in a variety of colors, while hot peppers (like chili and cayenne) are rich in capsaicin, a chemical that’s used in topical creams that reduce pain and inflammation.

Tomatoes:

Juicy red tomatoes, specifically, are rich in lycopene, which has been shown to reduce inflammation in the lungs and throughout the body. Cooked tomatoes contain even more lycopene than raw ones, so tomato sauce works, too

Ginger and Turmeric

These spices, common in Asian and Indian cooking, have been shown in various studies to have anti-inflammatory properties. “While the evidence in terms of RA inflammation is not very strong, they are vegetables—and part of a healthy, vegetable-rich diet,” says Dr. Costenbader.

Garlics and onions

There’s a good reason why these pungent vegetables are known for their immunity-boosting properties. In test-tube and animal studies, garlic has been shown to work similarly to NSAID pain medications (like ibuprofen), shutting off the pathways that lead to inflammation. Onions contain similar anti-inflammatory chemicals, including the phytonutrient quercetin and the compound allicin, which breaks down to produce free radical-fighting sulfenic acid.

olive oil:

“Anything that fits into a heart-healthy diet is probably also good for inflammation—and that includes healthy, plant-based fats like olive oil,” says Dr. Zashin, author of Natural Arthritis Treatment. In fact, a 2010 Spanish study found that the Mediterranean diet’s myriad health benefits may be largely due to its liberal use of olive oil, especially the extra-virgin kind. The compound oleocanthal, which gives olive oil its taste, has been shown to have a similar effect as NSAID painkillers in the body.

Berries;

All fruits can help fight inflammation, because they’re low in fat and calories and high in antioxidants. But berries, especially, have been shown to have anti-inflammatory properties—possibly because of anthocyanins, the powerful chemicals that gives them their rich color.

Cherries:

In a 2012 presentation, Oregon Health & Science University researchers suggested that tart cherries have the “highest anti-inflammatory content of any food.” Studies have found that tart cherry juice can reduce the inflammation in lab rats’ blood vessels by up to 50%; in humans, meanwhile, it’s been shown to help athletes improve their performance and reduce their use of anti-inflammatory pain meds.