High calcium in blood may signal cancer

High levels of calcium in blood, a condition known as hypercalcaemia, can be used by doctors as an early indication of certain types of cancer, says a study, indicating that a simple blood test may help prevent the deadly disease. The risk is particularly prominent among men.

High calcium in blood may signal cancer

While the connection of hypercalcaemia to cancer is well known, this study has, for the first time, shown that often it can predate the diagnosis of cancer in primary care. Hypercalcaemia is the most common metabolic disorder associated with cancer, occurring in 10 to 20 percent of people with cancer.

“We wanted to look at the issue from a different perspective and find out if high calcium levels in blood could be used as an early indicator of cancer and therefore in the diagnosis of cancer,” said Fergus Hamilton, who led the research from University of Bristol in Britain. For the study, the researchers analysed the electronic records of 54,000 patients who had elevated levels of calcium and looked at how many of them went on to receive a cancer diagnosis.

In men, even mild hypercalcaemia conferred a risk of cancer in one year of 11.5 percent. If the calcium was above limits, the risk increased to 28 percent. In women, the risks were much less, with the corresponding figures being 4.1 percent and 8.7 percent.

In men, 81 percent of the cancer associated with hypercalcaemia was caused by lung, prostate, myeloma, colorectal and other haematological cancers.
In women, cancer was much less common.

There are a number of possible explanations for this but we think it might be because women are much more likely to have hyperparathyroidism, another cause of hypercalcaemia, Hamilton added. “Men rarely get this condition, so their hypercalcaemia is more likely to be due to cancer,” he explained.

The study appeared in the British Journal of Cancer.
Source: mid day

 


Health Benefits of Guava

The health benefits of guava include the treatment of diarrhea, dysentery, constipation, cough, cold, skin care, high blood pressure, weight loss and scurvy.

Health Benefits of Guava

Many of you may have tasted this mouth-watering treat, or have at least seen or heard about it. Guava is very common in Asian countries, but is increasingly available in the western world, particularly as more of its health benefits are revealed. It is a somewhat round or pear-shaped seasonal fruit, and is light green, yellow, or maroon in color on the outside when it is ripe. Guava also has white or maroon flesh and lots of small hard seeds enveloped in very soft, sweet pulp. It is eaten raw (ripe or semi-ripe) or in the form of jams and jellies.

This popular fruit is a powerhouse of nutrients. If the traditional adage says that “An apple a day keeps the doctor away” in Europe and Americas, the phrase is probably changed to “A few guavas in the season keeps the doctor away for the whole year” in the Indian Subcontinent and places where guavas typically grow. Its scientific name is Psidium Guajava.

What makes guava special is that protecting the fruit does not require excessive use of chemical pesticides as in the case of grapes, apple, and other so-called “exotic” fruits. It is one of the least chemically treated and sprayed fruits.

Health Benefits of Guava

Some of the surprising and brilliant health benefits are listed below.

Weight loss: Guava is very helpful for those who want to lose weight without compromising their intake of proteins, vitamins and fiber. Guava is very high in roughage and rich in vitamins, proteins and minerals, but it has no cholesterol and a low number of digestible carbohydrates. It is a is very filling snack and satisfies the appetite very easily. Guava, especially raw guava, also has far less sugar as compared to apples, oranges, grapes, and other fruit. Adding a medium-sized guava to your lunch and you will not feel hungry again until the evening. Ironically, it can also help with weight gain in lean, thin people. This is probably due to its wealth of nutrients, which keep the metabolism regulates and helps to promote the proper absorption of nutrients.

Diabetes: In a related benefit to blood pressure mentioned above, an intake of guava can also help those patients who suffer from diabetes. The high level of dietary fiber in guava helps to regulate the absorption of sugar by the body, which decreases the chances of major spikes and drops in insulin and glucose in the body. Studies have shown that consuming guava can help prevent the appearance of type-2 diabetes.

Eyesight: Guavas are extremely good sources of vitamin-A, which is well known as a booster for vision health. It can help slow down the appearance of cataracts, macular degeneration, and general health of the eyes. It can not only prevent degradation of eyesight, but even an improvement in eyesight once it has begun to degrade.

Cancer Prevention: One of the most celebrated and important benefits of adding guava to your diet is its ability to inhibit the growth and metastasis of cancerous cells. There have been numerous studies done in recent years on guava’s effects primarily on prostate cancer, breast cancer, and oral cancers. Guava leaf oil is extremely successful as an anti-proliferative substance, and has actually been shown to be more effective than some leading modern medicines in reducing cancerous growth. Guavas are also rich in lycopene, a powerful antioxidant that has been shown to be wildly successful in reducing prostate cancer risk. That same antioxidant has also shown to inhibit the growth of breast cancer cells, although further human trials need to be done.

Finally, the naturally high levels of vitamin-C in guavas, which are four times higher than the levels found in oranges (the traditional vitamin-C powerhouse), provides the immune system a huge boost in antioxidants. Antioxidants are the major lines of defense against the proliferation of free radicals in the body, which are one of the main causes of serious conditions like cancer and heart disease. Therefore, adding guava to your diet has numerous ways in which it helps you stay health and cancer-free.

Scurvy: Guava can outdo many other fruits, including orange and other citrus fruits, in terms of its concentration of vitamin-C. A deficiency of vitamin-C can cause scurvy, and proper intake of vitamin-C is the only known remedy for that dangerous disease. In fact, guavas contain 5X more vitamin-C than oranges, which are often heralded as the absolute best source of that beneficial vitamin.

Diarrhea & dysentery: Guava is very rich in astringents (compounds that make your gums feel tighter and fresher). After you chew guava leaves, eat a raw guava, or use some guava-based toothpaste), your mouth feels healthier, and the astringent qualities also add substance to loose bowels and reduce symptoms of diarrhea. These astringents are alkaline in nature and have disinfectant and anti-bacterial properties, thus helping to cure dysentery by inhibiting microbial growth and removing extra mucus from the intestines. Furthermore, other nutrients in guava such as vitamin-C, Carotenoids and potassium, strengthen and tone the digestive system while simultaneously disinfecting it. Guava is also beneficial in treating gastroenteritis for the same reasons stated above.

Thyroid Health: Guavas are a good source for copper, which is an important part of regulating thyroid metabolism by helping to control hormone production and absorption. The thyroid gland is one of the most important glands in the body for regulating hormones and organ system function, so guava can help balance your health in many ways.

Constipation: Guava is one of the richest sources of dietary fiber in terms of fruit. Its seeds, if ingested whole or chewed, serve as excellent laxatives. These two properties of guava help the formation of healthy bowel movements, and aid the body in retaining water and thoroughly cleaning your intestines and excretory system. It is said that constipation alone can lead to 72 different types of ailments, so any help with constipation is beneficial. Your total health is undeniably affected by proper digestion, and more importantly, proper excretion. Frequent consumption of guava can ensure both.

Brain Health: Another of the tremendous positive benefits of guavas is the presence of B3 and B6 vitamins. B3 (also known as niacin) can increase blood flow and stimulates cognitive function. B6 is a great nutrient for brain and nerve function. Therefore, eating guava can help you increase brain function and sharpen you focus.

Cough & cold: Juice of raw and immature guavas or a decoction of guava-leaves is very helpful in relieving coughs and colds by reducing mucus, disinfecting the respiratory tract, throat and lungs, and inhibiting microbial activity with its astringent properties. Guava has one of the highest quantities of vitamin-C and iron among fruits, and both are proven to be preventive against colds and viral infections. In some areas of India, roasted ripe guava is used as a remedy against extreme cases of cough, cold, and congestion. Ripe guava should be avoided by people who are suffering from cough and cold, as it can exacerbate the problem, and one should also avoid drinking water immedaitely after eating guava as it can lead to a soar throat.

Skin care: Guavas can improve the texture of your skin and help you to avoid skin problems more than even the highest ranked beauty creams or skin toner gels. This is chiefly due to the abundance of astringents in the fruit (more astringent is present in immature guavas) and in its leaves. Your skin can benefit from either eating the fruits (this helps tighten your muscles apart from your skin) or by rinsing your skin with a decoction of its immature fruit and leaves. It will tone up and tighten the area of loosened skin where you apply it. In addition to the astringents, guava is very rich in vitamin-A, B, C and potassium which are good antioxidants and detoxifiers, which keep your skin glowing and free from signs of premature aging, wrinkles and other dermal disorders.

High blood pressure: Guava helps reduce cholesterol in the blood and prevents it from thickening, thereby maintaining the fluidity of blood and reducing blood pressure. Studies have shown that food lacking fiber (such as refined flour) add to blood pressure, due to its quick conversion to sugar. Guava, being very rich in fiber and hypoglycemic in nature, helps reduce blood pressure.

Other benefits: There are so many health benefits of guava, it is hard to know where to begin. It is important to know that guava helps control diabetes and protects the prostate. The juice of guava leaves has been known to cure toothaches, swollen gums & oral ulcers, and the juice speeds up the healing process of wounds when applied externally. Finally, it reduces the frequency of convulsions, epilepsy, and bacterial infections.

As with many alternative foods and supplements, there is little risk in eating them in natural form, but you must do your due diligence when taking it in medical forms. Be cautious when adding any new medicinal form of guava into your diet, and it is better to stick to eating guava in its natural form as a raw fruit.

Source: organic facts


New affordable way to stabilize haemoglobin discovered

A research team has found a way to stabilize hemoglobin, the oxygen carrier protein in the blood, a discovery that could lead to the development of stable vaccines and affordable artificial blood substitutes.

The new approach by UConn research team involves wrapping the polymer poly (acrylic acid) around hemoglobin, protecting it from the intense heat used in sterilization and allowing it to maintain its biological function and structural integrity.

In addition to having potential applications in the stabilization of vaccines and development of inexpensive artificial blood, the stabilizing polymer also allows vaccines and other biomedical products to be stored for longer periods without refrigeration. It could also have applications in biomaterials, biosensors, and biofuels.

‘Protein stability is a major issue in biotechnology,’ says Challa V. Kumar, UConn professor of chemistry and biochemistry and the primary investigator on the project. ‘What we’ve done is taken this protein molecule and wrapped it up in a polymer chain in order to stabilize it. In thermodynamics terms, we have restricted the entropy of the denatured state of the protein and stabilized it beyond our expectations.’

‘The system also exhibits a high degree of reversibility. The protein can be denatured and renatured many, many times. This is the very first example of its kind in the literature of all protein science. No one has ever been able to achieve this kind of stability for proteins.’

As part of its research, the team chose to examine the feasibility of using hemoglobin as an artificial blood substitute. Hemoglobin, when extracted from blood, breaks down and is toxic in its pure form.

Since hemoglobin is the critical oxygen carrier protein in blood, Kumar and his team are looking at ways of stabilizing hemoglobin in its natural form so that it retains its activity and stays harmless when administered as a transfusion agent. This could lead to a new substitute for human blood, which is frequently in short supply. Blood shortages are expected to get worse in coming years, as more and more people in the world are likely to need blood transfusions, Kumar said

Source: Health India