First ever retrograde gene therapy performed on human heart


An Indian origin surgeon has performed a historic first retrograde gene therapy, a novel procedure designed to deliver stem cells to the heart to repair damaged muscle and arteries in the most minimally invasive way possible.

Amit Patel, MD, director of Clinical Regenerative Medicine and Tissue Engineering and an associate professor in the Division of Cardiothoracic Surgery at the University of Utah School of Medicine performed the therapy on American actor, Ernie Lively.

Patel started investigating cell and gene-based therapies for the treatment of heart disease 12 years ago, but only recently received FDA approval to try the therapy on Lively, who was the first of several patients anxious to receive the treatment.

Patel and his team came up with the idea of retrograde heart therapy, a concept that has been discussed for 50 years.

“The genes basically act like a light house with a bright signal. They say, ‘ How can we help the ships that need to get to the port – which is the heart -get there. When the signal, or the light from the SDF-1, which is that gene, shows up, the stem cells from not inside your own heart and from those that circulate from your blood and bone marrow all get attracted to the heart which is injured, and they bring reinforcements to make it stronger and pump more efficiently,” Patel said.

Source: truth dive

8 Interesting facts about your heart

Did you know these cool facts about your heart?

1.The average adult heart beats 72 times a minute; 100,000 times a day; 3,600,000 times a year; and 2.5 billion times during a lifetime.

2. The heart produces enough energy to drive a truck 20 miles. So,in a lifetime, that is equivalent to driving to the moon and back!

3. The heart pumps nearly 1.5 million barrels of blood during an average lifetime which is enough to fill 200 train tank cars.

4. Laughter really works wonders for your heart and is perfect remedy for stress .A good hearty laugh can send 20% more blood flowing through your entire body. So indulge yourself in funny movies and create a group of jovial and cheerful people.

5. The stethoscope was invented by French physician Rene Laennec when he felt it was inappropriate to place his ear on his large-buxomed female patients’ chests.

6. A woman’s heart typically beats faster than a man’s. The heart of an average man beats approximately 70 times a minute, whereas the average woman has a heart rate of 78 beats per minute

7. Studies show Monday blues affect the heart the most as the majority of heart attacks occur between the hours of 8 -9 am on Mondays.

8. It is thought that the heart got its love association in the ancient Greek city of Cyrene due to the Silphium plant with its heart-shaped seed pods that grew in the region.

Source: Zee news