medical news

US firm brings next generation pacemaker in India

St Jude Medical Inc, a global medical device company, today announced the launch of next generation pacemaker in India.

The NYSE-listed firm announced the first commercial implant of `Allure Quadra’, a cardiac resynchronisation therapy pacemaker (CRT-P), in the country.

The first-to-market quadripolar pacemaker system offers more pacing options for patients with heart failure (HF), a company release said here.

Quadripolar leads allow for increased implant efficiencies, which clinical data indicates can result in fewer surgical revisions. Broad clinical evidence on the advantages of the quadripolar technology has been documented in more than 100 publications worldwide, it said.

Explaining how this new technology works, Anil Saxena of Fortis Escorts Hospital, said: “Historically, pacing systems that treat heart failure included a lead with only one electrode in the heart. Later, these were replaced by leads with two electrodes.

“Nearly 40 per cent of patients do not effectively benefit from traditional pacing due to potential complications all of which require repeat surgeries.”

The new technology has four electrodes and 10 programmable pacing configurations, allowing electro-physiologists to manage their patients with greater flexibility and improved patient outcomes, Saxena said.

The worldwide prevalence of heart failure has been rising over the last few decades. More than 26 million people globally suffer from HF, with a prevalence rate in India estimated to range from 1.3 to 4.6 million people.

Why chocolates, olive oil and tea are healthy for you

Researchers are focusing on the healthful antioxidant substances in red wine, dark chocolate, olive oil, coffee, tea, and other foods and dietary supplements.

Researchers are focusing on the healthful antioxidant substances in red wine, dark chocolate, olive oil, coffee, tea, and other foods and dietary supplements.

The American Chemical Society, the world’s largest scientific society, is holding a symposium on those substances during its 246th National Meeting and Exposition.

Reports in the symposium involve substances that consumers know best as ‘antioxidants,’ and that scientists term ‘ phenolic derivatives.’

These ingredients, found naturally in certain foods and sold as dietary supplements, have been linked with health benefits that include reducing the risk of heart disease and cance

Long-lasting chest pains indicator of heart attack!

Researchers have claimed that patients suffering long-lasting chest pain are likelier to have a heart attack than those with pain of a shorter duration.

James McCord, M.D., a cardiologist at Henry Ford Hospital on the research team, said that patients can experience varying strength, location, and duration of chest pain, asserting that the variety of symptoms any one patient may experience during a heart attack is a challenge to the physician who is trying to distinguish between patients who are having a heart attack and those who are not.

Of 426 patients included in the study, 38 (less than 9 percent) had a final diagnosis of heart attack, with average chest pain duration of 120 minutes, compared with 40 minutes in patients without heart attack.

In patients with chest pain lasting less than five minutes, there were no heart attacks and no deaths at 30 days.

McCord said that these findings suggest that patients with chest pain lasting less than five minutes may be evaluated as an out-patient in their doctor’s office; while patients with chest pain greater than 5 minutes, without a clear cause, should seek prompt medical evaluation in an emergency department.

Patients were interviewed during the study to determine medical history and demographics. Those with a diagnosis of heart attack were significantly older.

The study has been published in Critical Pathways in Cardiology.

 

Would you know if you were suffering from a hernia?

Did you know that you could suffer from a hernia almost suddenly? Or you might not even know you have one? Yup, doctors say that you may be diagnosed as having a hernia either during a regular medical checkup or it may strike suddenly, requiring a trip to the emergency room.

An abdominal hernia is a soft swelling seen over the abdominal wall and is a condition that afflicts more men than women. It’s formed due to an area of weakness in the muscles of the abdominal wall. In its initial stages, it is seen when the person is either standing, walking, coughing or lifting heavy objects and disappears when you lie down. At this stage, it can still be pushed back into the abdomen. It is when it becomes hard and cannot be pushed back that it causes a problem.

If you are obese, suffer from constipation, apply too much pressure while urinating, have a job that requires you to lift heavy weights, have people in your  immediate family who suffer from the condition or have had a recent surgery in the abdomen, you are more prone to developing a hernia. Even though statistically males are more prone to the disease that does not mean that women are can’t have them.

What makes this condition so unique and generally recurrent is the fact that it is a bilateral disease. This means that if a hernia forms on one side of the body (as in an inguinal hernia) it is very likely that the patient can develop one on the other side as well.

One of the most glaring and important symptoms is the formation of a bulge or lump on the surface of the body associated with pain. This usually happens only in areas like the stomach, groin or a part that has had some kind of surgical procedure. Other signs include a painful swelling that does not reduce on its own or on being pushed back, nausea, vomiting and abdominal bloating.  If left untreated, apart from being extremely painful and uncomfortable it can lead to twisting or torsion of the part that come out of the herniated space. If that is not treated at the earliest, the organ can die and become gangrenous which can then lead to the spread of toxins throughout the body, a condition also known as septicaemia. So getting treated quickly and appropriately is of utmost importance.

If you do suffer from these symptoms your doctor will most likely come to the conclusion that you are suffering from a hernia. In order to diagnose the condition he/she may do a physical exam to understand the severity of the condition. If he/she requires a better insight he/she may order an ultrasonography as well.

Based on the location of the hernia, your doctor will classify it into any one of the five types – inguinal hernias that are found in the groin, umbilical hernias found at the navel, ventral hernias found on the abdominal wall, incisional hernias present at a previous surgery site and femoral hernias found right above the thigh – and decide a method of treatment. Of all the hernias, almost 75% of the people suffer from an inguinal hernia and about 10% suffer from umbilical hernias.

Once diagnosed, the treatment options greatly depend on the severity of the symptoms. Most doctors will likely monitor the size of the hernia and its associated symptoms to see if it increases over a period of time. There are mainly two methods a doctor can use – a surgical method and a non surgical one.

In order to choose a non-surgical approach the doctor will see that there is not much swelling or bulging in the area. He will then use external help like that of a supportive truss to push back the hernia.

Surgical intervention is used only in more complicated and severe cases. And your doctor will choose to perform any one of the two types of surgeries – laproscopic and open surgery. While a laproscopic surgery is conservative and involves the use of a camera and a scope inserted into the body to fix the hernia, an open surgery is more invasive and requires a large incision along the part where the hernia is present.

How hernia surgery works is that it strengthens the wall of the abdomen by the placement of a prosthetic mesh. This mesh acts as a bridge in the area of muscle weakness. The body tissues grow into the mesh thus repairing the muscle gap, strengthening the abdominal muscle and helps repair the hernia.

While anyone who is fit to undergo general anaesthesia can have a hernia repair surgery, the choice of using an open surgery or laparoscopic surgery greatly depends on the type of hernia. For example laparoscopy is especially performed for an inguinal hernia, since they usually tend to be recurrent and bilateral. A laparoscopic approach is better for quick recovery and is less invasive. In the case of a small inguinal hernia or an umbilical hernia, it has to be treated with open surgery.

 

Anorexia linked to how cholesterol processes in our body

Scientists have linked the eating disorder anorexia to variants in a gene coding for an enzyme that regulates cholesterol metabolism.

The study suggests that anorexia could be caused in part by a disruption in the normal processing of cholesterol, which may disrupt mood and eating behavior.

For this project-the largest-ever sequencing study of anorexia – Nicholas J. Schork, a professor at The Scripps Research Institute (TSRI) worked with an international team of collaborators representing more than two dozen research institutions.

The project made use of genetic information from more than 1,200 anorexia patients and nearly 2,000 non-anorexic control subjects.

For an initial “discovery” study in 334 subjects, the researchers catalogued the variants of a large set of genes that had already been linked to feeding behavior or had been flagged in previous anorexia studies.

Of more than 150 candidate genes, only a handful showed statistical signs of a linkage with anorexia in this group of subjects.

One of the strongest signs came from the gene EPHX2, which codes for epoxide hydrolase 2-an enzyme known to regulate cholesterol metabolism. ”

The team followed up with several replication studies, each using a different cohort of anorexia patients and controls, as well as different genetic analysis methods. The scientists continued to find evidence that certain variants of EPHX2 occur more frequently in people with anorexia.

Schork noted that people with anorexia often have remarkably high cholesterol levels in their blood, despite being severely malnourished.

The study has been published online in the journal Molecular Psychiatry.

 

New vaccine promises to treat AIDS

Researchers have developed a vaccine that seems to have the capability of completely clearing an AIDS-causing virus from the body.

The promising vaccine candidate that is being developed at OHSU’s Vaccine and Gene Therapy Institute is being tested through the use of a non-human primate form of HIV, called simian immunodeficiency virus, or SIV, which causes AIDS in monkeys.

Louis Picker, M.D., associate director of the OHSU Vaccine and Gene Therapy Institute, said that the latest research suggests that certain immune responses elicited by a new vaccine may also have the ability to completely remove HIV from the body.

The Picker lab’s approach involves the use of cytomegalovirus, or CMV, a common virus already carried by a large percentage of the population. In short, the researchers discovered that pairing CMV with SIV had a unique effect.

They found that a modified version of CMV engineered to express SIV proteins generates and indefinitely maintains so-called “effector memory” T-cells that are capable of searching out and destroying SIV-infected cells.

T-cells are a key component of the body’s immune system, which fights off disease, but T-cells elicited by conventional vaccines of SIV itself are not able to eliminate the virus.

The SIV-specific T-cells elicited by the modified CMV were different. About 50 percent of monkeys given highly pathogenic SIV after being vaccinated with this vaccine became infected with SIV but over time eliminated all trace of SIV from the body.

In effect, the hunters of the body were provided with a much better targeting system and better weapons to help them find and destroy an elusive enemy.

The research has been published today by the journal Nature.

Roche drug works in early-stage breast cancer

The Food and Drug Administration has issued a positive review of a breast cancer drug from Roche that could soon become the first pharmaceutical option approved for treating early-stage disease before surgery.

In documents posted online, FDA scientists said women who received the drug Perjeta as initial treatment for breast cancer were more likely to be cancer-free at the time of surgery than women who received older drug combinations. Although the results come from mid-stage trials of the drug, FDA scientists recommended accelerating approval of the drug.

That step is reserved for groundbreaking drugs to treat life-threatening diseases.

Perjeta was first approved last summer to treat women with a subtype of breast cancer that has already spread to other parts of the body. But Roche’s Genentech unit is now seeking approval to use the drug at a much earlier stage of the disease: after diagnosis and before surgery to remove the tumor.

Surgery to remove tumors is the first step in treating virtually all forms of cancer. If approved, Perjeta would be the first cancer drug approved for use as a pre-surgical step. Using cancer drugs before surgery is still experimental, but doctors hope the approach could help shrink tumors to make them easier to remove. In some breast cancer cases, a tumor that is easier to operate on could allow women to keep their breasts, rather than having them surgically removed.

On Thursday, the FDA will ask an outside panel of cancer specialists whether Perjeta’s benefits outweigh its risks for treating early-stage breast cancer. Among other questions, the experts will be asked whether the preliminary results reported by Genentech are likely to result in longer overall survival for patients. The government agency isn’t required to follow the group’s advice, though it often does.

The panel will review a 417-woman study comparing Perjeta in different combinations against older breast cancer treatments. When Perjeta was combined with Herceptin, another Genentech drug, and standard chemotherapy, 39 percent of women saw their cancer reach undetectable levels. Only 21 percent of women experienced the same results from taking Herceptin and chemotherapy alone. After drug treatment all the women received standard breast surgery to remove any cancerous tumors. Genentech says this surgery allowed researchers to confirm the presence or absence of cancer.

Last year the FDA released guidelines for studying breast cancer drugs in the pre-surgical setting, with the aim of accelerating approval of promising therapies. Perjeta is the first drug to undergo FDA review since those recommendations were released. If approved, it could encourage more drugmakers to study cancer drugs for early-stage use.

“Despite advances in systemic therapy of breast cancer, there remains a need to expedite drug development and approval of highly effective therapies for patients with high-risk early-stage breast cancer,” the FDA states in its review.

Like Herceptin, Perjeta only works in a subset of about 20 percent of breast cancer patients who have tumors that overproduce a protein known as HER-2, which makes cancer cells rapidly divide and grow.

Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute. About 6,000 to 8,000 deaths per year are attributed to the HER-2 form of the disease.

FDA scientists stress in their review that Genentech’s results are preliminary and will have to be confirmed in future trials. The company only measured the patients’ immediate response to the drug, and did not submit follow-up data showing whether the cancer returned or whether women ultimately lived longer. But agency scientists said the company’s approach “is reasonably likely to predict clinical benefit,” and noted that Genentech is already enrolling patients in a late-stage trial that could confirm the results.

Since the early 1990s the FDA has granted accelerated approval to dozens of drugs based on promising early results, on the condition that their effectiveness is confirmed in later studies. That policy has been praised by patients with HIV, cancer and other deadly diseases where access to experimental treatments can mean life or death.

But the flipside of the program means removing drugs from the market if their initial promise isn’t confirmed by later studies. In 2011 the FDA was criticized by some cancer patients when it revoked breast cancer approval for another Genentech drug, Avastin. The FDA concluded that the drug did not help breast cancer patients live longer or bring enough other benefit to outweigh its dangerous side effects. The drug is still approved to treat colon cancer and other forms of the disease.

The FDA is scheduled to make a decision on whether to approve Perjeta for early-stage breast cancer by Oct. 31.

Source: Fox news

9 ways to eliminate sugar cravings

According to the American Heart Association, the average American consumes approximately 16 teaspoons more added sugar than is recommended per day.

Sugar stimulates the brain to release serotonin, the “feel good” chemical, which provides a natural high. The endorphins released after eating sugar calm and relax us, leaving us wanting more. Eliminating a sugar addiction can be difficult, but following these steps can greatly reduce cravings and make it easier to kick the habit for good.

Nix the artificial sweeteners.  Artificial sweeteners have not been proven to curb sugar cravings. The taste, artificial or real, will have the same effect on the body creating the same cycle of wanting more and more.

Eat protein. Protein deficiency can contribute to sugar cravings as the body searches for a quick energy source. Adding protein to every meal ensures that the body always has fuel to access and maintains a steady blood sugar level, preventing any spikes and crashes.

Eliminate or reduce processed foods. The amount of sugar in processed food is usually underestimated. Something as seemingly innocent as whole-wheat crackers can have as much as 4 grams of sugar per serving. Always read the label to double check the sugar content, or steer clear of packaged foods altogether.

Eat a balanced diet. Eating too much of one flavor profile can create extreme cravings for the opposite flavor. A diet high in salty foods tends to create cravings for sweet foods. Listen to your body and take note of what you’re eating to find balance with a variety of flavors.

Sweeten up with vegetables. Sweet vegetables such as carrots, sweet potatoes, podded peas, beets and sweet bell peppers can provide you with a quick burst of energy when you need a pick me up. By regularly incorporating these sweet flavors you can more easily keep intense sugar cravings away since you’ll be satisfying the need for sweet flavors.

Season with sweet spices. Spices such as coriander, cinnamon, nutmeg, clove and cardamom will naturally sweeten foods without the need for added sweeteners, working wonders to reduce cravings.

Check your mineral levels. Magnesium is used in the regulation of glucose, insulin, and the neurotransmitter dopamine; a deficiency can manifest in the form of intense sugar cravings, especially for chocolate. Zinc is needed for proper insulin and glucose utilization; a deficiency can also lead to sugar cravings.

Supplement with L-glutamine. This amino acid has been found to help reduce, and even eliminate, cravings by helping to steady blood sugar. Add 500 milligrams three times a day with meals and an extra dose when a craving hits. Taking as little as a quarter teaspoon at the onset of a sugar craving should stop it in its tracks.

Get moving, and then rest. Being overtired will create a craving for a quick energy source, such as sugar, to counteract exhaustion. Instead, get plenty of sleep and move your body daily to reduce tension boost energy and diminish your chances of needing a quick sugar rush.

When a craving hits and feels uncontrollable remember that it won’t last for more than 20 minutes. Distract yourself until it passes. The more you resist the easier quicker your cravings will disappear.

Source: Fox news

Inducing labor linked with lower C-section rate

Pregnant women who are near their due date or have just passed it can have labor induced with drugs or other medical procedures — or they can simply wait for labor to start on its own.

Sometimes, there is a medical reason to induce labor, such as a woman having gestational diabetes, but in other cases, women undergo elective induction, when labor is induced without a medical reason. Now, a new study suggests that women who elect to induce labor are less likely to wind up having a cesarean section (or C-section) compared with women who give labor a longer chance to begin naturally.

Among women in the study who had previously had a baby, the odds of having a C-section for their current pregnancy were cut by about half in those who underwent elective induction. About 3 percent of these women who were induced wound up having a C-section, while about 7 percent of those who waited for labor to start on its own had the surgery, said study researcher Blair G. Darney, an obstetrics and gynecology researcher Oregon Health & Science University.

Girl with fatal brain infection is now discharged from hospital

A 12-year-old Arkansas girl who survived a rare and often fatal infection caused by a brain-eating amoeba says she is lucky to be alive.

 

A 12-year-old Arkansas girl who survived a rare and often fatal infection caused by a brain-eating amoeba says she is lucky to be alive.

Kali (KAY’-lee) Hardig, her parents and doctors spoke to reporters Wednesday before she was to be released from Arkansas Children’s Hospital.

Kali says she has missed playing with her dog and seeing friends after being hospitalized in July.

The girl was diagnosed with an infection caused by a brain-eating amoeba. Health officials say there were 128 reported infections in the United States between 1962 and 2012. Before Kali, doctors could only point to one known survivor in the U.S. and another in Mexico.

Health officials believe Kali became sick after a trip to an Arkansas lake. The amoeba is often found in warm, fresh water.

This article is appeared in fox news