Autoimmune diseases may soon become history

An immunologist has said that with some prompting, the protein STING can turn down the immune response or even block its attack on healthy body constituents like collagen, insulin and the protective covering of neurons – targets of the debilitating diseases.

Medical College of Georgia researchers saw STING’s critical role play out after they injected into the bloodstream submicroscopic DNA nanoparticles, engineered carriers for delivering drugs or genes into cells.

They learned that the magic is in STING, which recognizes the molecule that senses the DNA then prompts release of IDO, or indoleomine 2,3-dioxyegenase.

Dr. Andrew L. Mellor, immunologist at the Medical College of Georgia at Georgia Regents University said that the fact that STING is actually part of the DNA-sensing pathway tells us something we did not know before.

DNA nanoparticles apparently look to the body a lot like the debris that results when dying cells release DNA from their nucleus.

Researchers already knew there was a link between STING and immunity: the food-borne bacterium listeria releases cyclic dinucleotides to activate STING in cells it has infected.

When MCG researchers put the STING stimulus into the bloodstream, it results in suppression. Other scientists have generated the exact opposite effect by injecting STING stimulating reagents under the skin.

In the bloodstream, there are a lot of immune cells called phagocytes that ingest the submicroscopic particles that wind up in the fluid portion of the cell, called the cytoplasm, where most cellular activity happens.

There, sensors detect the DNA and trigger signaling that leads to expression of IDO. In this complex interplay, STING appears essential to recognizing the molecule that recognizes the DNA.

The study has been published in the Journal of Immunology.


Copper can destroy highly infectious norovirus

      Copper and copper alloys can rapidly           destroy norovirus – the highly-                       infectious sickness bug, scientists have       discovered.

Worldwide, norovirus is responsible             for more than 267 million cases of                 acute gastroenteritis every year,                     researchers said.

The virus, for which there is no specific treatment or vaccine, can be contracted from contaminated food or water, person-to-person contact, and contact with contaminated surfaces, meaning surfaces made from copper could effectively shut down one avenue of infection.

The study, which was designed to simulate fingertip-touch contamination of surfaces, showed norovirus was rapidly destroyed on copper and its alloys, with those containing more than 60 per cent copper proving particularly effective.

Copper alloys have previously been shown to be effective antimicrobial surfaces against a range of bacteria and fungi.

The research reported rapid inactivation of murine norovirus on alloys, containing over 60 per cent copper, at room temperature but no reduction of infectivity on stainless steel dry surfaces in simulated wet fomite and dry touch contamination.

The rate of inactivation was initially very rapid and proportional to the copper content of alloy tested. Viral inactivation was not as rapid on brass as previously observed for bacteria but copper-nickel alloy was very effective.

One of the targets of copper toxicity was the viral genome and a reduced number of the gene for a viral encoded protein, VPg (viral-protein-genome-linked), which is essential for infectivity, was observed following contact with copper and brass dry surfaces.

“The use of antimicrobial surfaces containing copper in clinical and community environments, such as cruise ships and care facilities, could help to reduce the spread of this highly infectious and costly pathogen,” lead author Sarah Warnes, from the Centre for Biological Sciences at the University of Southampton, said.

“Copper alloys, although they provide a constant killing surface, should always be used in conjunction with regular and efficient cleaning and decontamination regimes using non-chelating reagents that could inhibit the copper ion activity,” said Warnes.

“Although the virus was identified over 40 years ago, the lack of methods to assess infectivity has hampered the study of the human pathogen,” Co-author Professor Bill Keevil, from the University`s Institute for Life Sciences, added.

“The virus can remain infectious on solid surfaces and is also resistant to many cleaning solutions. That means it can spread to people who touch these surfaces, causing further infections and maintaining the cycle of infection. Copper surfaces, like door handles and taps, can disrupt the cycle and lower the risk of outbreaks,” Keevil said.

The study was published in the journal PLOS ONE.


Cinnamon may help diabetics

Cinnamon, a common kitchen spice, may improve blood sugar levels for patients with type 2 diabetes, new research has found.

In a review study, researchers looked at data collected from 10 randomised control led trials involving 543 patients with type 2 diabetes.

These studies compared people who took cinnamon in a pill form, in doses ranging from 120 milligrammes to 6 grams a day, for a period of four to 18 weeks, to people who did not take cinnamon.

They found that people with type 2 diabetes who took cinnamon supplements had lower fasting plasma glucose levels compared with people who didn`t take them.
The most popular form of the supplement, which was used in six out of 10 trials, was Cinnamomum cassia, which participants were advised to take before, during or after their meals, `LiveScience` reported.

The review also found that cinnamon benefited several important measures of heart health: It reduced total cholesterol, LDL “bad” cholesterol and triglyceride levels, and increased HDL “good” cholesterol.

“When we combined the results of all the trials, we found that in patients with type 2 diabetes, there was a benefit on blood glucose and cholesterol levels,” said study researcher Olivia Phung, an assistant professor of pharmacy practice at Western University of Health Sciences in Pomona, California.

Preliminary studies have suggested that the compound, cinnamaldehydein, is responsible for cinnamon`s health effects.

Researchers suspect this substance may stimulate the release and effect of insulin, providing cinnamon its power to improve blood sugar.

“By enhancing insulin activity, it`s assumed there`d be better control of blood glucose,” Phung told the website.

The researchers have not yet determined the exact dose of cinnamon that may be helpful for people with type 2 diabetes, or the length of time or frequency the supplement should be taken.

The study was published in the journal The Annals of Family Medicine.


India gets WHO praise on polio front, no case in 30 months

WHO today lauded India`s efforts in eradicating polio and said the country has not reported a single case of polio in the last 30 months.

“You did it. For 30 months you have not got a single case of polio,” WHO Director General Margaret Chan said while addressing the meeting of Health Ministers of South-East Asia Region in the presence of President Pranab Mukherjee.

She said India achieved the feat even as 194 countries in the world were speculating whether it can interrupt the transmission of polio.

She also urged nations of the region to adopt universal healthcare access for all.
“I want to urge countries in this region. Please continue to champion universal access to healthcare. That is the platform to deliver healthy human capital that is important for sustainable development in the future,” she said.

The WHO DG complimented India`s health-care initiatives in improving the health of its mothers and children and said, “This country is moving in a big way to promote better health to their women and to their children.”

She also lauded the role of Health Minister Ghulam Nabi Azad saying, “This country is very fortunate to have a minister totally dedicated to health.”

She also expressed concern over the growing incidence of heart disease which saw 9.4 million deaths every year and said high blood pressure has contributed to it.

“The scale of the problem is a challenge,” she said, adding that more than one in three adults across the world are suffering from high blood pressure.

Chan was here to attend the 31st Health Ministers` meeting of South-East Asia region which comprises of almost 1.8 billion people.

 


What leads to caffeine addiction?

Caffeine users can become dependent on or addicted to caffeine and may have difficulty reducing their consumption.

Researchers have now described the prevalence of caffeine dependence, clinically relevant indicators of functional impairment among caffeine users, and the criteria for making a diagnosis of caffeine use disorder.

Steven Meredith and Roland Griffiths, Johns Hopkins University School of Medicine (Baltimore, MD), Laura Juliano, American University (Washington, DC), and John Hughes, University of Vermont (Burlington), reviewed the published research on caffeine dependence. In the article “Caffeine Use Disorder: A Comprehensive Review and Research Agenda.”

They posed an agenda for future research that would include clinical, epidemiologic, and genetic investigations to lead to a better understanding of the clinical signs and the prevalence of caffeine dependence, as well as the risk factors and best approaches for treating caffeine addiction.

The study is published in Journal of Caffeine Research.


Men more prone to fall ill than women

mental illness increases the risk of developing a physical illness by 10 times in both men and women.

A new study has revealed that men are more likely to develop physical illness than women.

The research conducted by St. Michael’s Hospital over a period of 10-years found that having a mental illness increases the risk of developing a physical illness by 10 times in both men and women.

However, women with mental illness tend to develop a physical illness a year earlier than men, according to the study by Dr. Flora Matheson, a scientist in hospital’s Centre for Research on Inner City Health.

Women were at a 14 percent reduced risk, compared to men, of developing physical illness; meaning that men are disadvantaged from a health perspective.

The study, which used data from the Institute for Clinical Evaluative Sciences, was conducted to see whether gender also had an impact on the relationship between mental illness and onset of physical illnesses.

There is growing interest in studying the link between physical and mental illness as new studies indicate people with serious mental illness have higher rates of physical ailments such as metabolic syndrome, hypertension and cardiovascular, viral and respiratory diseases.

The study is published online in the Journal of Epidemiology and Community Health.


Microbe Transplants Treat Diseases That Drugs Can’t Fix

Billie Iverson may be getting up there, but for an 86-year-old, she’s still plenty active.

“I take trips, and I go do my own shopping, and I take myself to the doctor,” Iverson says. “I do everything. I don’t let anything stop me.”

But one day, she got hit with something she’d never experienced — the worst case of the runs ever.

For days at a time, off and on for weeks, the problem kept coming back. Iverson eventually got so weak, she ended up in for days at a time, off and on for weeks, the problem kept coming back. Iverson eventually got so weak; she ended up in a nursing home.

“I just thought maybe I wasn’t going to make it,” she says. “I thought I was going to die.”

Finally, Iverson’s daughter took her to see Colleen Kelly, a doctor at Brown University. Kelly knew right away what was going on.

“It’s very classic, this pattern,” Kelly says. “We’ve seen hundreds of cases over the last couple of years at our program.”

Kelly’s program specializes in the microbes that live in our digestive systems — trillions of bacteria, viruses, fungi and other mostly helpful microbes whose genes scientists collectively call the human microbiome .

The problem, she told Iverson, started when antibiotics prescribed for another health problem disrupted the community of benign organisms in her intestines, leaving her vulnerable to a really bad bug — a bacterium called Clostridium Difficile

“You can almost look at C. diff as … the prototypical example,” Kelly says, of how a disruption in the human microbiome can result in disease.

Kelly is among a growing number of doctors who are starting to use what scientists are learning about our microbiomes to help prevent, diagnose, and treat many illnesses. For Iverson, she proposed something that may sound pretty radical — what doctors call a fecal transplant

“It’s really almost like an organ transplant,” Kelly says. “You’re taking this whole community of microorganisms from one person, [and] transplanting them into another person. Then these things … take root, colonize and kind of restore that balance.”

Iverson says she initially found the idea repulsive. But she felt so desperate that she agreed to try it.

“I was scared to death, honey,” Iverson says. “I’m an old lady. I’ve got one foot in the grave and the other on the banana peel.”

The procedure turned out to be really easy. And it worked — virtually overnight. “It stopped,” Iverson says. “Right away. I’m feeling good now. I’m feeling great.”

What happened to Iverson is the most dramatic example of how doctors are manipulating the microbiome in lots of ways to help lots of different kinds of patients.

For one thing, Kelly says doctors are testing the use of the transplants in other illnesses, such as colitis, Crohn’s disease and diabetes. And there’s even talk of trying the treatment for obesity.

“We’re at a really interesting point in medicine where we’ve come to appreciate the microbiome and that [these organisms] have really integral roles in … energy metabolism, and immune function, and all of these other things,” Kelly says.

At the same time, researchers are looking for more subtle ways to fix our microbiomes. For starters, they’re trying to remove the “yuk” factor from microbiome transplants by figuring out exactly which microorganisms patients really need and giving them just those. And there’s tons of research involving so-called probiotics — live cultures of supposedly beneficial microbes, typically included in yogurt or other foods or supplements probiotics are meant to be swallowed, in hopes that they’ll outcompete pathogenic bacteria and restore a healthy balance.

The evidence is really mounting to the point where I think it’s undeniable that the ingestion of live bacteria — safe bacteria in high numbers — has an overall beneficial effect on human health,” says colin hill of the University College Cork in Ireland.

Scientists are testing a long list of probiotics for a variety of health problems, including vaginal infections, colic in babies and weakened immune systems in the elderly. They’re also studying so-called prebiotics— non digestible carbohydrates meant as food for the good microbes.

Now, anyone who walks into a grocery store these days knows that hundreds of prebiotic and probiotic products are already on the market. You can’t watch TV or go on the Internet without hearing the kinds of claims the manufacturers of these products make.

The companies point to studies supporting their claims. But many experts say there are still huge questions about how safe such products are, how pure they are, and whether they really do what their makers say they do.

“All of those things together open up the opportunity for … the equivalent of snake oil salesmen related to probiotics or microbial treatments, or fecal transplants or whatever,” says Jonathan Eisen of the University of California, Davis.

And Eisen is not alone in his criticism. The Food and Drug Administration has big concerns. Those concerns include whether microbiome transplants might spread infections, or are being promoted for unproven uses, or whether they might actually increase the risk for some health problems.

“The gut microbiome can affect obesity, diabetes [and] a number of other disorders,” says Jay Slater, director of the FDA’s Division of Bacterial, Parasitic and Allergenic Products. “These are the kinds of concerns that would indicate that good long-term studies really should be done.”

So the FDA requires that doctors who want to do microbiome transplants for anything other than C-diff treatment get FDA approval first. And physicians must warn patients that, even for C-diff, the treatment is still experimental. Scientists studying probiotics have to put them through the same careful testing that regular drugs go through.

All this is really frustrating for many scientists. They argue that these regulatory roadblocks are holding up research and making it too hard for patients to get microbiome transplants.

“People are dying of C. diff,” says Kelly. “And people are living in this really terrible state. I see people who’ve lost their jobs, people who’ve become depressed because of just the feeling of utter hopelessness. And I think it’s really unethical to withhold the treatment from patients who need it.”

As for Iverson, she agrees that anyone who needs such a transplant should be able to get one.

“I think it’s terrific,” she says. “I think it’s the best thing that ever happened. This is like a step to heaven having this done.”


Mosquito ‘invisibility cloak’ discovered

A hand in a mosquito cage was not attractive when covered with the chemical

A naturally occurring substance found in human skin could yield a viable alternative to existing mosquito repellent, scientists say.

They say the chemical could help render people “invisible” to the insects.

At the American Chemical Society meeting, they revealed a group of compounds that could block mosquitoes’ ability to smell potential targets.

When a hand with these chemicals was placed in a mosquito filled enclosure, it was completely ignored.

The team says their work could help prevent the spread of deadly diseases.

Mosquitoes are among the most deadly disease-carrying creatures. They spread malaria, which in 2010 killed an estimated 660,000, according to the World Health Organization (WHO).

Ulrich Bernier of the United States Department of Agriculture (USDA) who presented the work, said his team was exploring other options to Deet – a repellent which some do not favour.

Buzzing off

In fact, earlier this year a team of scientists said that the widely used repellent was losing effectiveness.

“Repellents have been the mainstay for preventing mosquito bites… [but] we are exploring a different approach, with substances that impair the mosquito’s sense of smell. If a mosquito can’t sense that dinner is ready, there will be no buzzing, no landing and no bite,” said Dr Bernier.

It has long been known that some people are more attractive to mosquitoes than others, but now the team has pinpointed a group of chemical components secreted naturally, that can mask human smell from the blood-sucking insects.

Dr Bernier explained that hundreds of compounds on the skin makes up a person’s smell. In order to see what smells attracted mosquitoes, his team sprayed various substances onto one side of a cage.

It was the compounds that didn’t attract any mosquitoes that they looked at further and when sprayed on a human hand, the insects did not react or attempt to bite.

‘Invisible hand’

These chemical compounds, including 1-methylpiperzine, were found to completely block their sense of smell.

The compounds could be added into many cosmetics and lotions, Dr Bernier added.

“If you put your hand in a cage of mosquitoes where we have released some of these inhibitors, almost all just sit on the back wall and don’t even recognize that the hand is in there. We call that anosmia or hyposmia, the inability to sense smells or a reduced ability to sense smells.”

Commenting on the work, James Logan of the London School of Hygiene and Tropical Medicine, said it was exciting to find out exactly which chemicals repelled mosquitoes.

“Although we already have good repellents on the market, there is still room for new active ingredients. The challenge that scientists face is improving upon the protection provided by existing repellents.

“If a new repellent can be developed which is more effective, longer lasting and affordable, it would be of great benefit to travellers and people living in disease endemic countries,” Dr Logan told BBC News.

But he said that it would take many years before a new product would make it to market.

Source: BBC News/health


Lung cancer drug ‘could help treat ectopic pregnancy

A lung cancer drug could be given to women with ectopic pregnancies in a bid to help them avoid surgery.

A joint study by researchers in Edinburgh and Melbourne, Australia, found that combining a drug called gefitinib with existing treatment was more effective at curing the condition.

An ectopic pregnancy is when an embryo implants in the Fallopian tube.

It can be treated with drugs if identified early, but surgery is needed when it is more developed.

Each year, about 12,000 women in the UK have an ectopic pregnancy and the condition is responsible for up to 80% of pregnancy-related deaths.

The study, published in the journal Obstetrics and Gynaecology, involved a trial of 12 women.

Gefitinib, usually used to treat lung cancer, blocks a protein that is known to encourage cell growth, and which was found to be present in high levels at the site of ectopic pregnancies.

Scientists from the Edinburgh University’s medical research council centre for reproductive health, and the University of Melbourne, suggested that combining gefitinib with the conventional treatment – called methotrexate – could reduce the need to remove the Fallopian tube in a significant number of cases.

They said this would help a patient’s level of fertility.

The researchers also found that the drug combination was able to shorten the time it took to successfully treat ectopic pregnancies in women who did not need surgery.

Dr Andrew Horne, who led the study, said: “An ectopic pregnancy can be extremely stressful for the woman involved.

“If we can reduce the need for surgery, and thereby help fertility levels, then that would be an enormous benefit.

“Reducing the treatment time for women who do not need surgery would also have a significant impact in reducing the emotional stress of such a diagnosis.”

Researchers now plan to run a larger trial.

Source: BBC News


Magic ‘mushroom diet’? Experts scoff at weight-loss claim

A new diet fad claims that replacing one meal a day with mushrooms will help women shed fat, but only in certain parts of the body — the waist, hips and thighs — but not the bust.

The two-week diet, called the M Plan, according to the Daily Mail, has been touted by celebrities such as Kelly Osbourne and Katy Perry.

Experts say that there’s nothing magical about mushrooms — replacing one meal a day with any vegetable would help a person lose weight, said Katherine Tallmadge, a registered dietitian, and op-ed contributor to LiveScience.

And the claim about selective weight loss doesn’t hold up to science. “There’s no evidence that any diet … will help you lose weight in a particular spot,” Tallmadge said.

How people lose, and also gain, weight is determined largely by genetics, Tallmadge said, but factors such as age and smoking habits also play a role.

Studies show older women are more likely to gain weight around their belly, likely due to changing hormone levels, Tallmadge said. Smoking has also been linked to an increased risk of gaining weight in the midsection.

However, studies suggest that certain exercises may help people lose weight selectively: there’s evidence that walking is an effective exercise for helping people lose belly fat, Tallmadge said.