Suffering from Polycystic Ovarian Syndrome (PCOS)? Don’t lose hope

Suffering from Polycystic Ovarian Syndrome Don't lose hope

Are you experiencing irregular periods, weight gain, hair growth on the body and face, thinning of the hair on the head? Don’t ignore the symptoms as chances are you may be suffering from a condition called Polycystic Ovarian Syndrome (PCOS).

What is PCOS?

PCOS is an endocrine disorder which is associated with an excess of androgens or male hormones in the body. It leads to the formation of small cysts in the ovaries. According to experts, nearly 40% percent of teenagers today suffer from PCOS due to sedentary life or consumption of high calorie, high carb diet.

It is more commonly found in women living in urban areas than women residing in rural places as it is majorly a lifestyle disease. The exact cause of the disease is not known.

Symptoms of PCOS

Symptoms of PCOS include irregular, missed or scanty menstruation cycle, weight gain, excessive hair growth on chin, lower abdomen, thighs, facial hair and thinning of hair on your head.

Why worry if you have PCOS?

One of the major effect that PCOS have on a female body is that it leads to imbalance of hormones which may again interfere with the growth and release of eggs from the ovaries, thereby preventing ovulation and may lead to infertility in some cases.

Also, since the body becomes resistant to insulin, a women is at risk of obesity, hypertension, cholesterol and uterine cancer.

Is it possible to have a baby with PCOS?

The good news is that one need not be depressed as PCOS can be managed with medicines to some extent. A women can easily conceive by adopting a healthy lifestyle, eating right and maintaining healthy weight.

Treatment of PCOS

Treatment of PCOS depends partially on the woman’s stage of life. For younger women, treatments can include inducing exercises in daily routine, diet modifications and medication. Experts also prescribe the usage of birth control pills to control the menstrual cycle thereby decreasing androgen levels in the female body.

Some other treatments like Progesterone therapy is also adviced by doctors.

Source: zee news


Male hormones play an important role in female fertility

Several fertility clinics across the country are beginning to administer testosterone, either through a patch or a gel on the skin, to increase the number of eggs produced by certain women undergoing in vitro fertilization (IVF). Women are also purchasing the over-the-counter supplement DHEA, which is converted by the body into testosterone, to boost their chances of pregnancy with IVF.

A few clinical trials support the use of testosterone given through the skin, while others have shown no benefit of DHEA – also used in attempts to slow aging and enhance muscle mass – in increasing pregnancy and birth rates in women who don’t respond well to IVF therapy. Lacking a large and convincing body of data on the topic, the jury is still out as to whether male hormones such as testosterone improve female fertility.

A new study suggests that male hormones, also called androgens, help drive the development of follicles – structures that contain and ultimately release an egg that can be fertilized by a man’s sperm. Published in the Proceedings of the National Academy of Sciences, the research also details how male hormones boost the production of follicles in mice. Authors believe the study provides potential biological targets to enhance fertility in women with diminished ovarian reserve, who produce few or no follicles in response to IVF drugs designed to boost follicle development.

“There is a raging debate in the reproductive endocrinology field about what male hormones are doing in female fertility,” said Stephen R. Hammes, M.D., Ph.D.,senior study author and professor of Endocrinology at the University of Rochester School of Medicine and Dentistry. “Our study doesn’t solve the controversy, but, along with some earlier seminal studies from other groups, it does tell us that we can’t dismiss male hormones. They might actually be doing something useful.”

Using multiple animal models and cell experiments, Hammes and lead study author Aritro Sen, Ph.D., research assistant professor of Endocrinology at the medical school found that male hormones promote follicle development in two ways. First, they prevent follicles from dying at an early stage. They do this by ramping up a molecule that stops cells from self destructing, a process called apoptosis. Hammes and Sen speculate that if a woman doesn’t have enough androgens (male hormones), more of her follicles may be dying and fewer progressing to a mature stage when they produce and release an egg.

Using multiple animal models and cell experiments, Hammes and lead study author Aritro Sen, Ph.D., research assistant professor of Endocrinology at the medical school found that male hormones promote follicle development in two ways.

First, they prevent follicles from dying at an early stage. They do this by ramping up a molecule that stops cells from self destructing, a process called apoptosis. Hammes and Sen speculate that if a woman doesn’t have enough androgens (male hormones), more of her follicles may be dying and fewer progressing to a mature stage when they produce and release an egg.

Second, androgens make ovarian cells more sensitive to follicle-stimulating hormone or FSH, which promotes follicle growth. They do this by creating more FSH receptors – molecules on the surface of ovarian cells that jumpstart the follicle making process in response to the hormone.

When the team administered small doses of androgens to mice that were taking the equivalent of medications given to women undergoing IVF therapy, they developed more mature, egg-containing follicles than mice that didn’t receive androgens.

The androgen-treated female mice also released larger numbers of eggs with ovulation.

The study has been published in the Proceedings of the National Academy of Sciences.

Source: Medical express