New guidance limits antibiotics for common infections in children

Every year, as many as 10 million American children are at risk for side effects from prescribed antibiotics that most likely won’t help them get over an upper respiratory infection, according to the U.S. Centers for Disease Control and Prevention (CDC).

Many of these upper respiratory infections are caused by viruses, which are not helped by antibiotics.

“Our medicine cabinet is empty of antibiotics to treat some infections,” said CDC Director Tom Frieden, M.D., M.P.H. in a press release. “If doctors prescribe antibiotics carefully and patients take them as prescribed we can preserve these lifesaving drugs and avoid entering a post-antibiotic era.”

The overuse of antibiotics, a significant factor fueling antibiotic resistance, is the focus of a new report Principles of Judicious Antibiotic Prescribing for Bacterial Upper Respiratory Tract Infections in Pediatrics by the American Academy of Pediatrics (AAP) in collaboration with the CDC.

The new report was released to coincide with Get Smart About Antibiotics Week which runs from November 18 – 24.

The AAP has outlined responsible antibiotic prescribing for three common upper respiratory tract infections in children:

• Ear infections
• Sinus infections
• Sore throats

“Many people have the misconception that since antibiotics are commonly used that they are harmless,” said co-author of the report Dr. Lauri Hicks in a press release. “Taking antibiotics when you have a virus can do more harm than good.”

Antibiotic resistance occurs when bacteria evolve and are able to outsmart antibiotics, making even common infections difficult to treat.

Each year more than two million Americans get infections that are resistant to antibiotics and 23,000 die as a result, according to a CDC report from September 2013.

AMA recommendation for clinicians: 3 Principles of Responsible Antibiotic Use

1. Determine the likelihood of a bacterial infection: Antibiotics should not be used for viral diagnoses when a concurrent bacterial infection has been reasonably excluded.

2. Weigh benefits versus harms of antibiotics: Symptom reduction and prevention of complications and secondary cases should be weighed against the risk for side effects and resistance, as well as cost.

3. Implement accurate prescribing strategies: Select an appropriate antibiotic at the appropriate dose for the shortest duration required.

Source: health2fit


Norma Spear: a tragic case of neglect and dehydration

71-year-old from Birmingham died after becoming dehydrated, losing 35lb in five weeks despite being under the supervision of care workers.

When Carol Clay dropped her mother off at the Druids Meadow residential home on the outskirts of Birmingham it was only meant to be a six-week stay.

Norma Spear, a lifelong Brummie approaching her 71st birthday, was increasingly falling while alone at home due to worsening arthritis. After one particularly nasty fall put her in hospital, it was agreed that Norma should move temporarily into a home in September 2010 while her house underwent refurbishment.

Norma, a fiercely independent woman, was against the idea. “She liked her own way and she liked routine,” says Carol, 53, who was Norma’s only child. “She got very frightened of medical people.”

Before arthritis set in Norma would often help out elderly friends who lived close by, pruning flowers in the garden and keeping them company over mugs of tea. Even when her joints began to stiffen she preferred not to be seen in public in a wheelchair, opting for a Zimmer frame instead.

“That’s me done then, isn’t it?” Norma joked with her daughter when told of the plan to move into care. Three years on, the words have lost their humor.

At first Norma settled in well. Carol would visit every day and take her mother out for trips. Aside from some early quibbles over how tough it was to get the staff’s attention, Druids Meadow seemed a safer place to be than home alone.

But things soon turned for the worse. As a coroner would later find, Norma was repeatedly failing to eat enough. She developed a urinary tract infection and begun drinking less and less water, despite being under the supervision of staff.

The situation came to a head in October while Carol was away for the week in London visiting the National History Museum with her daughter Jessica, now 9.

“As the week went on, mum got more and more incoherent, to the point where the phone stopped being answered,” Carol recalls. Despite reassurances from the care home staff, she cut short her trip after sensing something was wrong and rushed to the home.

“From the moment I got there it was apparent that some major change had taken place,” says Carol. “She was dehydrated; there was no doubt about it. … She was very quiet, very sleepy. She would mutter a word and drop off mid-sentence.”

Carol was insistent that her mother was dangerously dehydrated: her inner lips were dry and flaky; she became delirious, envisioning snakes coiled by the light fittings. Yet despite repeated requests for a doctor to treat her mother it was not until November 1 – Norma’s 71st birthday – that she was examined, according to the coroner.

Throughout her birthday Norma sat slumped and motionless in a wheelchair, head down. Three days later she was in hospital. Five days later she was dead.

When Norma passed away on November 6 2010 she weighed just five stone. During five weeks in the home she had lost 35lb. At an inquest earlier this year, neglect was found to have played a part in her death, as did dehydration.

“The failures I found are gross because they were so terribly simple,” concluded Birmingham’s deputy coroner Sarah Ormond-Walshe. “Without one or more of these gross failures, Norma Spear would have survived.”

Speaking almost three years to the day since Norma’s passing, Carol says she still feels guilt. “If I hadn’t gone to London, she would probably have lived … I have got to carry that guilt for the rest of my days,” she says.

But there is also anger at the Britain’s care system. “I don’t actually blame the staff at the care home,” she says. “I blame the total lack of protocol and training which we have in all our assisted care homes.”

When told that more than 1,000 people died dehydrated in care homes over the past decade, Carol says she is saddened but doubts 10 years from now nothing will have changed. “I honestly don’t believe it will stop.”

Source: Healcon


70,000 HIV cases detected in China since January

Around 70,000 new HIV cases were reported in China in the first nine months of the year, bringing the total number of people living with HIV/AIDS to 434,000.

From January to September, 80.7 million people received tests for HIV, an increase of 8.9 percent from the same period last year, reported Xinhua citing a National Health and Family Planning Commission statement.

A total of 3,413 treatment organisations were set up in 31 provincial-level regions.

China tested 7.43 million pregnant women for HIV/AIDS in the first nine months of the year to prevent possible mother-to-child transmission, the statement said.

Source: Two circles

 


Women lose more work days than men due to illness: Study

Women have a slightly lower chance of falling sick compared to men, but they lose more days at work from being ill, a new study on Indian healthcare system by Global Development Network says.

 According to the study, women work fewer days in a year and as a result, lose almost 15 per cent of their work days to illness, while men lose only six per cent.

“Being ill, therefore, has a greater impact on a woman’s income than that of a man. On the other hand, women’s health expenditures tend to increase more compared to men,” the GDN Working Paper ‘Managing Healthcare Provision and Health Outcomes through Local Governance’ says.

The paper reveals significant positive impact of local governance and empowerment of women, and complex and sometimes surprising similarities in illness and treatment impact on men and women.

“Sickness is significantly reduced through improved access to drinking water, clean surroundings and awareness about health campaigns. These factors reduce the use of public and private healthcare, as well as private health expenditures,” it says.

GDN is a New Delhi-based public international organisation that builds research capacity in development globally.

The study says that a family’s inherited wealth reduces the incidence of illness almost equally for both men and women and reduces private health expenditures slightly more for women than for men.

“This is suggestive of some discrimination within families with regard to healthcare access,” says the study.

Individual empowerment as a result of inheritance of land by a woman has an overall positive impact on her health and use of healthcare, it says.

While in terms of access to health facilities, women are not at a disadvantage, they benefit significantly in terms of health from individual empowerment through land inheritance, it says.

The study also finds significant positive impact on both men and women due to political empowerment of women as a result of the reservation of the Pradhan’s (chief councilor) position for women.

Source: Business Standard


Six health benefits of carrots

One of the world’s healthiest foods is Carrot. Carrots are a great way to infuse good nutrition and flavor into your diet. With this power food, you get vitamin A and a host of other powerful health benefits.

– Carrots are rich in beta-carotene, which is converted into vitamin A in the liver which is further converted to rhodopsin, a purple pigment necessary for night vision.

– Beta-carotene in carrot acts as an antioxidant to cell damage done to the body through regular metabolism thus it helps slow down the aging of cells.

– Carrots have not only beta-carotene but also alpha-carotene and lutein which lowers the risk of cardiovascular diseases.

– Studies show that carrots reduce the risk of lung cancer, breast cancer and colon cancer.

– Vitamin A and antioxidants in carrots protect the skin from harmful effects of sun rays. Vitamin A prevents premature wrinkling, acne, dry skin, pigmentation, blemishes, and uneven skin tone.

– Carrots also considerably reduce cholesterol levels because the soluble fibers in carrots bind with bile acids.

Source: Health me up


Negative results may ‘not always’ imply reduced breast cancer risk

A new study has found that women who are members of families with BRCA2 mutations but who test negative for the family-specific BRCA2 mutations are still at greater risk for developing breast cancer compared with women in the general population.

Women with certain mutations in their BRCA1 or BRCA2 genes are at increased risk for breast cancer. However, the study suggested that it may not always be true.

“We found that women who test negative for family-specific BRCA2 mutations have more than four times the risk for developing breast cancer than the general population,” Gareth R. Evans from University of Manchester in the United Kingdom, said. “We also found that any increased risk for breast cancer is largely limited to BRCA2 families with strong family history and other genetic factors.

Evans said that it is likely that these women inherit genetic factors other than BRCA-related genes that increase their breast cancer risk. About 77 single nucleotide polymorphisms are linked to breast cancer risk.

He said that identification of additional SNPs is necessary to understand why some of the BRCA-negative women from BRCA families are at higher risk.

The authors noted that specialists should use caution when stating that a woman’s breast cancer risk is the same as that of the general population following a negative test, because it may not be true for some women who come from BRCA2 families with a strong family history.

The study is published in journal Cancer Epidemiology, Biomarkers and Prevention.

Source: ANI


Mother-to-child HIV infections decreasing: UN

The U.N. Children’s Fund says it is alarmed about increasing HIV and AIDS rates among adolescents over the last seven years and is advocating an aggressive program that includes condom distribution and antiretroviral treatment.

In a more positive development, UNICEF found that mother-to-child transmission of the HIV virus has been dramatically reduced and estimated that some 850,000 cases were prevented in low- and middle-income countries.

Its 2013 Stocktaking Report on Children and AIDS released Friday said AIDS-related deaths among those aged 10 to 19 increased between 2005 and 2012 from 71,000 to 110,000. About 2.1 million adolescents were living with HIV in 2012.

Nearly 90 percent of children newly infected with HIV live in just 22 countries. All except one are in sub-Saharan Africa.

“If high-impact interventions are scaled up using an integrated approach, we can halve the number of new infections among adolescents by 2020,” said UNICEF Executive Director Anthony Lake. “It’s a matter of reaching the most vulnerable adolescents with effective programs – urgently.”

High-impact interventions include condoms, antiretroviral treatment, prevention of mother-to-child transmission, voluntary medical male circumcision, communications for behavior change and targeted approaches for at-risk and marginalized populations.

UNICEF found dramatic improvement in prevention of new HIV infections among infants. Some 260,000 children were newly infected with HIV in 2012, compared to 540,000 in 2005.

New, simplified life-long antiretroviral treatment known as Option B+ provides the opportunity to effectively treat women with HIV and to prevent the transmission of the virus to their babies during pregnancy, delivery, and through breastfeeding.

The treatment involves a daily one-pill regimen.

Some of the most remarkable successes were in sub-Saharan Africa. New infections among infants declined between 2009 and 2012 by 76 percent in Ghana, 58 percent in Namibia, 55 percent in Zimbabwe, 52 percent in Malawi and Botswana and 50 percent in Zambia and Ethiopia.

UNICEF said that globally, the number of AIDS-related deaths overall fell by 30 percent between 2005 and 2012

Source: Deccan Chronicle

 


How superbugs develop antibiotic resistance

A team of researchers used quantitative models of bacterial growth to discover the bizarre way by which antibiotic resistance allows bacteria to multiply in the presence of antibiotics.

According to UC San Diego biophysicists understanding how bacteria harbouring antibiotic resistance grow in the presence of antibiotics is critical for predicting the spread and evolution of drug resistance.

In the study, the researchers found that the expression of antibiotic resistance genes in strains of the model bacterium E. coli depends on a complex relationship between the bacterial colony’s growth status and the effectiveness of the resistance mechanism.

According to Terry Hwa, a professor of physics and biology who headed the research, the interaction between drug and drug-resistance is complex because the degree of drug resistance expressed in a bacterium depends on its state of growth, which in turn depends on the efficacy of drug, with the latter depending on the expression of drug resistance itself.

For a class of common drugs, the researchers realized that this chain of circular relations acted effectively to promote the efficacy of drug resistance for an intermediate range of drug doses.

The use of predictive quantitative models was instrumental in guiding the researchers to formulate critical experiments to dissect this complexity. In their experiments, E. coli cells possessing varying degrees of resistance to an antibiotic were grown in carefully controlled environments kept at different drug doses in “microfluidic” devices-which permitted the researchers to manipulate tiny amounts of fluid and allowed them to continuously observe the individual cells.

Hwa and his team found a range of drug doses for which genetically identical bacterial cells exhibited drastically different behaviours: while a substantial fraction of cells stopped growing despite carrying the resistance gene, other cells continued to grow at a high rate.

This phenomenon, called “growth bistability,” occurred as quantitatively predicted by the researchers’ mathematical models, in terms of both the dependence on the drug dose, which is set by the environment, and on the degree of drug resistance a strain possesses, which is set by the genetic makeup of the strain and is subject to change during evolution.

“Exposing this behavior generates insight into the evolution of drug resistance,” says Hwa. “With this model we can chart how resistance is picked up and evaluate quantitatively the efficacy of a drug.”

The study is published in the journal Science.

Source: ANI


4 ways to prevent a hangover

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Try these tips for preventing a hangover and avoid the nasty symptoms of drinking too much

How much should you drink?

There’s no set rule for how much you can drink and avoid a hangover, although of course the more you drink, the more likely you’ll get one, and the worse it’ll be. The Centre for Addiction and Mental Health (CAMH) in Toronto advises women to have no more than two standard drinks per day and nine per week. “These are low-risk, but not no-risk, guidelines,” says Wende Wood, a psychiatric pharmacist with CAMH. “They differ depending on the person. In general, women should drink less than menbecause we have a higher percentage of body fat versus water.” That means you’ll reach a higher blood-alcohol concentration than your male counterpart—even if you consume the same number of drinks.

Here are four simple strategies that you can try at your next get-together to keep a hangover at bay.

1. Eat before you drink

Food slows down the absorption of alcohol. Plus, you’ll feel fuller, and may drink at a slower pace.

2. Slow down

Don’t have more than one drink per hour. This is the maximum rate at which most people’s bodies can process alcohol.

3. Switch it up

Alternate between alcoholic and non-alcoholic drinks (or water). You will stay hydrated and slow the pace at which the alcohol gets absorbed into your bloodstream.

4. Stick with light-colored drinks

Think vodka, gin or white wine. Dark-colored drinks such as rum, whisky and red wine contain chemicals called congeners, which are more likely to produce hangover symptoms.

Source: Best Health

 


Five health benefits of apples

You may have heard the saying “An apple a day keeps the doctor away” many times, but do you know the reasons why?

1. Apples are good source of soluble fiber which helps to ease intestinal disorders and control insulin levels.

2. Flavanols and procyanidins in apples may work in the body to exert cardiovascular benefits, suggests study.

3. Apples have low calorie content, around 50-80 calories per apple, and has no fat or sodium.

4. Apples are packed with B-complex vitamins (riboflavin, thiamin, and vitamin B-6) which help in maintaining red blood cells and the nervous system.

5. Phytonutrients in apples help protect the body from the harmful effects of free radicals.

Source: Zee News