Scorpion’s venom can make cancer cells ‘glow’

Scorpion’s venom can make cancer cells ‘glow’

In what can alter the course of cancer treatment in the near future, researchers have found a compound that appears to pinpoint all of the malignant cells in a patient’s body. The twist is that the compound’s main ingredient is a molecule that is found in the sting of a deadly scorpion. The compound called chlorotoxin is found in the venom of the death stalker scorpion known as leiurus quinquestriatus. It gives malignant cells a bright fluorescent sheen so surgeons can easily spot them, wired.com reported.

‘A scorpion-venom concoction that makes tumours glow sounded almost too outlandish to be true in the beginning. But with generous donations from individuals, the fluorescent scorpion toxin is now in Phase I clinical trials,’ informed Jim Olson from the renowned Seattle-based Fred Hutchinson Cancer Research Centre that developed the technique, called ‘Tumour Paint’. (Read: Cancer vaccine developed to boost lifespan of patients)

Scorpion venoms are cocktails of numerous individual toxins that attack different targets within a victim’s body. Olson and his team found that chlorotoxin did not attach just to brain tumours — it grabbed onto all sorts of cancers, from those that affect the skin to those that destroy the lungs. In lab experiments, Olson began to inject fluorescent-tipped chlorotoxin into mice — the compound lit up cancer cells that no other technology could identify. In one instance, the chlorotoxin illuminated a clump of just 200 malignant cells that were burrowed deep within a wad of fat. ‘That was the point we learned that the technology was far more sensitive than an MRI,’ Olson was quoted as saying

Source: the health site


The weed that causes cancer may well kill it

Tobacco-Nicotiana-sylvestris--I

Tobacco has been associated with and much maligned for causing cancers. Researchers have now found that the tobacco plant’s defence mechanism could well work in humans to destroy invading cancer cells.

A molecule called NaD1 is found in the flower of the tobacco plant that fights off fungi and bacteria. This compound also has the ability to identify and destroy cancer, the team discovered.

“This is a welcome discovery whatever the origin,” Mark Hulett from La Trobe Institute for Molecular Science in Melbourne was quoted as saying.

The molecule, found in nicotiana sylvestris (flowering tobacco) plant, forms a pincer-like structure that grips onto lipids present in the membrane of cancer cells.

It then effectively rips them open, causing the cell to expel its contents and explode.

According to researchers, this universal defence process could also potentially be harnessed for the development of antibiotic treatment for microbial infections.

The pre-clinical work is being conducted by the Melbourne biotechnology company Hexima. “The preliminary trials have looked promising,” said Hulett.

The study was published in the journal eLife.

Source: Times of India